2022-RA-442-ESGO Fallopian tube cytological findings in women undergoing salpingectomy and correlation with the adnexal pathology

Introduction/Background Epithelial Ovarian Cancer (EOC) is still the most lethal gynecological malignancy, with approximately 21,410 new cases and 13,770 deaths in USA 2021. Many theories have been proposed terms of clarifying etiology carcinogenesis -mechanism EOC. Based on latest trends, ovarian, fallopian tube, peritoneal cancer are incorporated into same group as it suggested that high-grade extrauterine tumors serous histology originate from tube. Methodology We ex vivo collect salpingeal epithelial cellsfrom fibria directly fresh tube specimensfrom women undergoing salpingectomy for any indication. The cytomorphological characteristics cells subsequently being evaluated categorised malignant non -malignant. Finally, ipsilateral adnexaeare examined SEE-FIM (Sectioning Extensively Examining FIMbriated End) protocol pathology reports corelated cytological findings. Our research ongoing designed to include a total 300 patients order confirm sensitivity specificity cytology method early diagnosis malignancies. Results So far, we obtained 343 brushingsfrom 214 patients. regarding distinguishing non-malignant tumors,was 69.64% (95% CI: 55.90% – 81.22%), while its 75.96% 70.59% 80.79%). Cytology’s positive predictive value (PPV) was 16.33% 12.57% 20.67%), negative (NPP) reached 92.77% 89.56% 95.04%). In general, diagnostic accuracy evaluation reaches 74.93% 66.99% 79.43%). Conclusion Salpingeal cytomorphologic appears be promising detect adnexal cancer. study, aims long term validate oncological efficacy tubal an tool against